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MDMA (ECSTASY OR MOLLY)

Other Names: Adam, E, XTC
RSAC_MCM_MDMA_LG

Also known as: Ecstasy, Molly, E, XTC, X, Adam, Hug, Beans, Clarity, Lover's Speed, and Love drug

MDMA, short for 3,4-methylenedioxymethamphetamine, is most commonly known as Ecstasy or Molly. It is a man-made drug that produces energizing effects similar to the stimulants called amphetamines, as well as psychedelic effects, similar to the hallucinogens mescaline and LSD. MDMA is known as a “club drug” because of its popularity in the nightclub scene, at “raves” (all-night dance parties), and music festivals or concerts. MDMA’s effects generally last from 3 to 6 hours.

MDMA is a Schedule I substance, which means that the U.S. Government has determined that it has no medical benefit and a high potential for abuse. Researchers, however, continue to investigate the possible medical benefits, for example, with patients that have post-traumatic stress disorder (PTSD) and terminal cancer patients with anxiety. However, those patients are under strict medical supervision.

Most people who use MDMA take it in a pill, tablet, or capsule. The pills can be different colors and sometimes have cartoon-like images on them. Some people take more than one pill at a time, called “bumping.” The popular term “Molly” (slang for molecular) refers to the pure crystalline powder form of MDMA, usually sold in capsules. But this is mostly a marketing gimmick—testing on "Molly" seized by police shows a variety of other ingredients.

In fact, researchers and law enforcement have found that much of the Ecstasy sold today contains other harmful and possibly deadly drugs in addition to MDMA. In some recent cases, drugs sold as MDMA do not contain MDMA at all.  Frequently, MDMA is mixed with or replaced by synthetic cathinones, the chemicals in “bath salts. Some MDMA pills, tablets, and capsules have also been found to contain caffeine, dextromethorphan (found in some cough syrups), amphetamines, PCP, or cocaine.

Once an MDMA pill or capsule is swallowed, it takes about 15 minutes for the drug to enter the bloodstream and reach the brain. MDMA produces its effects by increasing the activity of three neurotransmitters (the chemical messengers of brain cells): serotonin, dopamine, and norepinephrine.

  • Serotonin—plays a role in controlling our mood, aggression, sexual activity, sleep, and feelings of pain. The extra serotonin that is released by MDMA likely causes mood-lifting effects in users. People who use MDMA might feel very alert, or “hyper,” at first. Some experience altered sense of time and other changes in perception, such as a more intense sense of touch. Serotonin also triggers the release of the hormones oxytocin and vasopressin, which play a role in feelings of love, sexual arousal, and trust. This may be why users report feeling a heightened sense of emotional closeness and empathy.
  • Dopamine—helps to control movement, motivation, emotions, and sensations like pleasure. The extra dopamine causes a surge of feelings of joy and increased energy
  • Norepinephrine—increases heart rate and blood pressure, which are particularly risky for people who have problems with their heart and blood circulation

Because MDMA increases the activity of these chemicals, some users experience negative effects. They may become anxious and agitated, become sweaty, have chills, or feel faint or dizzy.

Even those who don’t feel negative effects during use can experience negative after-effects. These are caused by the brain no longer having enough serotonin after the surge that was triggered by using MDMA. Days or even weeks after use, people can experience confusion, depression, sleep problems, drug craving, and anxiety, because the surge of serotonin caused by MDMA reduces the brain's supply of this important chemical.

Effects of Long-Term Use

Researchers are not sure if MDMA causes long-term brain changes or if such effects are reversible when someone stops using the drug. However, studies have shown that some heavy MDMA users experience problems that are long lasting, including confusion, depression, and problems with memory and attention.

The changes that take place in the brain with MDMA use affect the user in other ways as well. These include:

  • increases in heart rate and blood pressure
  • muscle tension
  • teeth clenching
  • nausea (feeling sick) and possible vomiting
  • blurred vision
  • faintness
  • chills or sweating
  • higher body temperature (can lead to serious heart, liver, or kidney problems)
  • increased risk for unsafe sex

Because MDMA does not always break down in the body, it can interfere with its own metabolism. This can cause harmful levels of the drug to build up in the body if it is taken repeatedly within short periods of time. High levels of the drug in the bloodstream can increase the risk for seizures and affect the heart's ability to beat normally.

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